Postdoc position IMMM, Le MansR&D engineer position in natural substances chemistry/ biochemistry

 

Company presentation

« Ouest Valorisation » is a « Société d’Accélération du Transfert de Technologies » or Technology Transfer Office (TTO) created in July 2012 through the government « Programme des Investissements d’Avenir ». Our mission is to add value to the results produced by public research laboratories in Brittany and Pays de la Loire regions, and to provide socio-economic actors with attractive innovation resources. We are working for 26 higher education and research establishments and organisms. SATT Ouest Valorisation is recruiting a R&D engineer in natural substances chemistry/biochemistry.

Find the SATT Ouest Valorisation news on http://www.ouest-valorisation.fr/en/home-page

 

 

Context

A post-doctoral position is open in the frame of the Valdemar program « Valorization of Haslea and marennine ». The marine diatom Haslea ostrearia synthesizes a blue-green pigment, named marennine.

Currently, the only known exploitation of this pigment is the greening of oysters in oyster ponds in Western France. So far, this use has remained empirical because of the difficulty in growing the microalgae in large scale and in marennine chemical structure identification. However, there is a great demand for natural blue pigments.

Valdemar will also benefit from the contribution of the European program H2020 GHaNA (The Genus Haslea, New marine resources for blue biotechnology and Aquaculture) (2017-2021).

 

The recruited post doc will be paid by SATT Ouest Valorisation and he/she will work at Le Mans University, at the Institut des Molécules et Matériaux du Mans and at the Mer-Molécules-Santé department, in collaboration with an interdisciplinary team composed by chemists, biologists, physicists, and also with foreign colleagues on secondment in France in the framework of the GHaNA project.

 

Under the responsibility of the maturation project leader of Ouest Valorisation and of the scientific coordinators of the Valdemar project, the recruited engineer will have to complete the determination of the marennine chemical structure and to study its physicochemical properties. To do that, he (or she) will use the recent results about the characterization of the glycosidic backbone and of a patent concerning a new method to obtain marennine by concentration of the Haslea culture supernatant.

 

 

Main activities

- complete the study of marennine chemical structure and identify the nature of the chromophore and its bond to the glycosidic backbone. The work will be carried out on the entire molecule and on the fragments obtained by chemical and enzymatic hydrolysis

- study of marennine physico-chemical properties (colorimetric properties, stability in formulations) in view of the applications in the food and cosmetic industries

- other species of blue Haslea have been recently discovered so the characterization would be also carried out on their pigments to make comparison and draw conclusions.

 

 

Candidate profile - Diplomas – Experience

 

- PhD in chemistry or biochemistry

- experience in extraction, purification and identification of natural compounds, preferably macromolecules

- familiarity with chromatography (HPLC) and Nuclear Magnetic Resonance analytical techniques

- autonomous, independent, proactive

- able to perform team work, to exploit the results by writing papers, reports and in oral presentations.

 

Contract - Location

18-months fixed-term contract

 

Institut des Molécules et Matériaux du Mans (IMMM, UMR CNRS 6283) and Laboratoire Mer-Molécules-Santé (MMS, EA 2160), Le Mans Université, Avenue Olivier Messiaen, 72085 Le Mans cedex 9, France

 

Scientific coordinators contact information for applications:

 

 

Prof. Jean-Luc Mouget

e-mail: jean-luc.mouget(at)univ-lemans.fr

téléphone: +33 (0)2 43 83 32 42

 

 

Dr. Pamela Pasetto

e-mail: pamela.pasetto(at)univ-lemans.fr

téléphone: +33 (0)2 43 83 33 35

 

 

 References

           

Gastineau R, Davidovich NA, Bardeau JF, Caruso A, Leignel V, Hardivillier Y, Jacquette B, Davidovich OI, Rince Y, Gaudin P, Cox EJ, Mouget JL. Haslea karadagensis (Bacillariophyta): a second blue diatom, recorded from the Black Sea and producing a novel blue pigment. Eur J Phycol 2012, 47, 469-479.

Gastineau R, Pouvreau JB, Hellio C, Morancais M, Fleurence J, Gaudin P, Bourgougnon N, Mouget JL. Biological activities of purified marennine, the blue pigment responsible for the greening of oysters. J Agr Food Chem 2012, 60, 3599-3605.

Gastineau, R., Turcotte, F., Pouvreau, J.-B., Morançais, M., Fleurence, J., Windarto, E., Semba Prasetiya, F., Arsad, S., Jaouen, P., Babin, M., Coiffard, L., Couteau, C., Bardeau, J.-F., Jacquette, B., Leignel, V., Hardivillier, Y., Marcotte, I., Bourgougnon, N., Tremblay, R., Deschênes, J.-S., Badawy, H., Pasetto, P., Davidovich, N. A., Hansen, G., Dittmer, J., Mouget, J.-L. Marennine, promising blue pigments from a widespread Haslea diatom species complex. Mar Drugs 2014, 12, 3161-3189.

R.Gastineau, F. S. Prasetiya, C. Falaise, B. Cognie, P. Decottignies, M. Morançais, V. Méléder, N.

Davidovich, F. Turcotte, R. Tremblay, P. Pasetto, J. Dittmer, J.-F.Bardeau, J.-B. Pouvreau, J.-L. Mouget, “Marennine-like pigments: blue diatom or green oyster cult?”, in "Blue Technologies: Production and Use of Marine Molecules",  Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. Stephane La Barre (Editor), Stephen S. Bates (Editor) ISBN: 978-3-527-34138-2, Nov 2018.

Mouget JL, Rosa P, Vachoux C, Tremblin G. Enhancement of marennine production by blue light in Haslea ostrearia. J Appl Phycol 2005, 17, 437–445

Pouvreau J-B, Morançais M, Fleury F, Rosa P, Thion L, Cahingt B, Zal F, Fleurence J, Pondaven P. Preliminary characterization of the blue-green pigment “marennine” from the marine tychopelagic diatom Haslea ostrearia (Gaillon/Bory) Simonsen. J Appl Phycol 2006, 18, 757-767.

Pouvreau, J.B., Morançais, M., Massé, G., Rosa, P., Robert, J.M., Fleurence, J., Pondaven, P., Purification of the blue-green pigment “marennine” from the marine tychopelagic diatom Haslea ostrearia (Gaillon/Bory) Simonsen. J Appl Phycol 2006, 18, 769–781.

Pouvreau, J.B., Morançais, M., Fleurence, J., Pondaven, P. Method for the quantification of the blue-green pigment qmarennineq synthesized by the marine diatom Haslea ostrearia (Gaillon/Bory) Simonsen using HPLC gel-filtration and photodi- ode-array detection. J Appl Phycol 2007, 19, 263–270.

Pouvreau JB, Morancais M, Taran F, Rosa P, Dufosse L, Guerard F, Pin S, Fleurence J, Pondaven P. Antioxidant and free radical scavenging properties of marennine, a blue-green polyphenolic pigment from the diatom Haslea ostrearia (Gaillon/Bory) Simonsen responsible for the natural greening of cultured oysters. J Agr Food Chem 2008, 56, 6278-6286.